L. Vogel, M. Gnott, C. Kröger-Koch, S. Görs, J.M. Weitzel, E. Kanitz, A. Hoeflich, A. Tuchscherer, A. Tröscher, J.J. Gross, R.M. Bruckmaier, A. Starke, L. Bachmann, H.M. Hammon.

Glucose metabolism and the somatotropic axis in dairy cows after abomasal infusion of essential fatty acids together with conjugated linoleic acid during late gestation and early lactation.

J Dairy Sci. 2021 Jan 14:S0022-0302(21)00044-8. doi: 10.3168/jds.2020-19321.


D. Ohde, M. Walz, C. Walz, A. Noce, J. Brenmoehl, M. Langhammer, A. Hoeflich.

Sex-Specific Control of Muscle Mass: Elevated IGFBPProteolysis and Reductions of IGF-1 Levels AreAssociated with Substantial Loss of Carcass Weight inMale DU6PxIGFBP-2 Transgenic Mice

Cells. 2020 Oct; 9(10): 2174. Published online 2020 Sep 26. doi: 10.3390/cells9102174


M. Walz, L. Chau, C. Walz, M. Sawitzky, D. Ohde, J. Brenmoehl, A. Tuchscherer, M. Langhammer, F. Metzger, C. Höflich, A. Hoeflich.

Overlap of Peak Growth Activity and Peak IGF-1 to IGFBP Ratio: Delayed Increase of IGFBPs Versus IGF-1 in Serum as a Mechanism to Speed up and down Postnatal Weight Gain in Mice.

Cells. 2020 Jun; 9(6): 1516. Published online 2020 Jun 22. doi: 10.3390/cells9061516


W. Liermann, C. T. Schäff, J. Gruse, M. Derno, J. M. Weitzel, E. Kanitz, W. Otten, A. Hoeflich, T. Stefaniak, H. Sauerwein, R. M. Bruckmaier, J. J. Gross, and H. M. Hammon.

Effects of colostrum instead of formula feeding for the first 2 days postnatum on whole-body energy metabolism and its endocrine control in neonatal calves.

J Dairy Sci. 2020 Apr; 103(4): 3577–3598. Published online 2020 Feb 20. doi: 10.3168/jds.2019-17708


A. Hoeflich, J. Pintar, B. Forbes.

Editorial: Current Perspectives on Insulin-Like Growth Factor Binding Protein (IGFBP) Research.

Front Endocrinol (Lausanne) 2018; 9: 667. Published online 2018 Nov 20. doi: 10.3389/fendo.2018.00667


A. Hoeflich, R. David, R. Hjortebjerg.

Current IGFBP-Related Biomarker Research in Cardiovascular Disease—We Need More Structural and Functional Information in Clinical Studies.

Front Endocrinol (Lausanne) 2018; 9: 388. Published online 2018 Jul 16. doi: 10.3389/fendo.2018.00388


K. Mense, J. Heidekorn-Dettmer, E., Y., R., S. Peter, M. Jung, C. Höflich, A. Hoeflich, M. Schmicke.

Increased Concentrations of Insulin-Like Growth Factor Binding Protein (IGFBP)-2, IGFBP-3, and IGFBP-4 Are Associated With Fetal Mortality in Pregnant Cows.

Front Endocrinol (Lausanne) 2018; 9: 310. Published online 2018 Jun 12. doi: 10.3389/fendo.2018.00310


Effects of Transport Duration and Environmental Conditions in Winter or Summer on the Concentrations of Insulin-Like Growth Factors and Insulin-Like Growth Factor-Binding Proteins in the Plasma of Market-Weight Pigs.

E. Wirthgen, S. Goumon, M. Kunze, C. Walz, M. Spitschak, A. Tuchscherer, J. Brown, C. Höflich, L. Faucitano, A. Hoeflich.

Front Endocrinol (Lausanne) 2018; 9: 36. Published online 2018 Feb 13. doi: 10.3389/fendo.2018.00036


D. Frieten, C. Gerbert,C. Koch, G. Dusel, K.Eder, A. Hoeflich, B. Mielenz, H.M. Hammon.

Influence of ad libitum milk replacer feeding and butyrate supplementation on the systemic and hepatic insulin-like growth factor I and its binding proteins in Holstein calves.

J Dairy Sci. 2017 Dec 13. pii: S0022-0302(17)31157-8. doi: 10.3168/jds.2017-13603.


C.Y. Um, S. Judd, W.D. Flanders, V. Fedirko & R.M. Bostick.

Associations of Calcium and Dairy Products with All-Cause and Cause-Specific Mortality in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Prospective Cohort Study.

Nutr Cancer. 2017 Nov-Dec;69(8):1185-1195. doi: 10.1080/01635581.2017.1367946. Epub 2017 Nov 10.


E. Wirthgen, M. Kunze, S. Goumon, C. Walz, C. Höflich, M. Spitschak, J. Brennmoehl, E. Kanitz, M. Tuchscherer, W. Otten, U. Gimsa, P. Schön, C. Manteuffel, A. Tuchscherer, R. Pfuhl, C. Metges, B. Stabenow, S. Erdmann, K. Schluricke, L. Faucitano, A. Hoeflich.

Interference of stress with the somatotropic axis in pigs – lights in new biomarkers

Sci Rep. 2017 Sep 21;7(1):12055. doi: 10.1038/s41598-017-11521-5.


U.S. Espelund, M. Bjerre, R. Hjortebjerg, T.R. Rasmussen, A. Lundby, A. Hoeflich A, B.H. Folkersen, C. Oxvig, J. FrystykJ.

Insulin-Like Growth Factor Bioactivity, Stanniocalcin-2, Pregnancy-Associated Plasma Protein-A, and IGF-Binding Protein-4 in Pleural Fluid and Plasma From Patients With Pulmonary Disease.

J Clin Endocrinol Metab. 2017 Sep 1;102(9):3526-3534. doi: 10.1210/jc.2017-00033.


Z. Meyer, C. Höflich, E. Wirthgen, S. Olm, H.M. Hammon, A. Hoeflich.

Analysis of the IGF-system in milk from farm animals - Occurrence, regulation, and biomarker potential.

Growth Horm IGF Res. 2017 Aug;35:1-7. doi: 10.1016/j.ghir.2017.05.004. Epub 2017 May 12. Review.

PMID: 28544872 [PubMed - in process] Free Article


C.T. Schäff, J. Gruse, J. Maciej, M. Mielenz, E. Wirthgen, A. Hoeflich, M. Schmicke, R. Pfuhl, P. Jawor, T. Stefaniak, H.M. Hammon.

Effects of Feeding Milk Replacer Ad Libitum or in Restricted Amounts for the First Five Weeks of Life on the Growth, Metabolic Adaptation, and Immune Status of Newborn Calves.

PLoS One. 2016 Dec 30;11(12): e0168974. doi: 10.1371/journal.pone.0168974. eCollection 2016.


E. Wirthgen, C. Höflich, M. Spitschak, C. Helmer, B. Brand, J. Langbein, F. Metzger, A. Hoeflich:

Quantitative Western ligand blotting reveals common patterns and differential features of IGFBP-fingerprints in domestic ruminant breeds and species.

Growth Horm IGF Res. 2016 Feb;26:42-9. doi: 10.1016/j.ghir.2015.11.001. Epub 2015 Nov 10.


M. Meyerholz, K. Mense, M. Lietzau, A. Kassens, M. Linden, H. Knaack, E. Wirthgen, A. Hoeflich, M. Raliou,  C. Richard, O. Sandra,  H. Schubert, M. Hoedemaker, M. Schmicke.

Plasma IGFBP-4 concentration decreased in dairy heifers towards day 18 in pregnancy.

J Vet Sci 2015, 16(4), 413-421.


M. Oster, W. Nuchchanart, N. Trakooljul, E. Muráni , A.  Zeyner, E.  Wirthgen, A. Hoeflich, S. Ponsuksili, K. Wimmers.

Methylating micronutrient supplementation during pregnancy influences foetal hepatic gene expression and IGF signalling and increases foetal weight.

Eur J Nutr. 2015


M. Bielohuby, S.H. Zarkesh-Esfahani, J. Manolopoulou, E. Wirthgen, K. Walpurgis, M.T. Khorasgani, Z.S. Aghili, I.R. Wilkinson, A. Hoeflich, M. Thevis, R.J. Ross, M. Bidlingmaier.

Validation of Plasma IGF-I as a biomarker to monitor exogenous growth hormone agonist and antagonist bioactivity in rabbits.

Dis. Model. Mech. September 19, 2014.


T. Laeger und E. Wirthgen, M. Piechotta, F. Metzger, C.C. Metges, B. Kuhla, A. Hoeflich.

Effects of parturition and feed restriction on concentrations and distribution of the insulin-like growth factor-binding proteins in plasma and cerebrospinal fluid of dairy cows.

J Dairy Sci. 2014 May; 97(5):2876-85


F. Krieger, N. Elflein, S. Saenger, E. Wirthgen, K. Rak, S. Frantz, A. Hoeflich, K.V. Toyka, F. Metzger, S. Jablonka.

Polyethylene glycol-coupled IGF1 delays motor function defects in a mouse model of spinal muscular atrophy with respiratory distress type 1.

Brain. 2014 May; 137(Pt 5):1374-93